C  Thermo Fisher Scientific Lafayette www.thermofisher.com Scientific leadership and innovation in RNAi, Gene Expression, qPCR/PCR Detection, and Molecular Biology technologies come together with the Thermo Scientific Dharmacon, Open Biosystems, ABgene, Finnzymes, and Fermentas product lines to provide world- leading solutions for gene analysis. C  Tolmar Fort Collins www.tolmar.com A fully integrated pharmaceutical company focused on the development, approval, and commercialization of specialty pharmaceutical products. TopGear Automation Denver www.topgearautomation.com Development and validation of biomarkers for environmental exposure, oncology, and related diseases. C  TopoGEN, Inc. Buena Vista www.topogen.com TopoGEN, Inc. is a mature biotech company that markets and sells R&D reagents globally in the anti-cancer and antibiotic space. We are also an established CRO specialized in high throughput drug screening in these areas. We have >10 global distributors and actively export products to Asia, the E.U and many other countries. TopoGEN is also well funded with multiple SBIR grants. UBP Bio Aurora www.ubpbio.com Manufactures and sells bioreagents related to the ubiquitin-proteasome pathway. The ubiquitinproteasome pathway is responsible for degradation of the majority of cellular proteins. C  Ultragenyx Pharmaceuticals California www.ultragenyx.com Ultragenyx is a biopharmaceutical company committed to bringing to patients novel products for the treatment of rare and ultra-rare diseases, with a focus on serious, debilitating genetic diseases. Founded in 2010, the company has rapidly built a diverse portfolio of approved therapies and product candidates aimed at addressing diseases with high unmet medical need and clear biology, for which there are no approved therapies. The company is led by a management team experienced in the development and commercialization of rare disease therapeutics. Ultragenyx’s strategy is predicated upon time and cost-efficient drug development, with the goal of delivering safe and effective therapies to patients with the utmost urgency. Upsher-Smith Laboratories, Inc. Denver www.upsher-smith.com Develops, manufactures and markets a vast range of prescription and over-the-counter products for cardiology, dermatology, women’s health and other areas. Sinfonia Biotherapeutics Boulder www.sinfoniabiotherapeutics.com Developing novel, bioreactor-delivered treatments for familial and genetically - defined orphan ​ neurodegenerative diseases. C  STAQ Pharma Denver www.staqpharma.com 503B Outsourcing facility. Focused on sterile, pre-filled syringes. C  Steadman Philippon Research Institute Vail www.sprivail.org Orthopedic sports medicine, SPRI is unlocking the secrets of healing, finding cures and enhancing lives through regenerative medicine, scientific research, innovation and education. Sudhin Biopharma Company Superior www.sudhinbio.com Sudhin Biopharma Co. develops novel continuous and more efficient biopharmaceutical manufacturing technologies. Its first product is single use disposable plastic BioSettler, which can be used to (i) remove dead cells and cell debris selectively while recycling live and productive cells back to the perfusion bioreactor, (ii) clarify cell culture broth at the end of fed-batch cultures, (iii) capture secreted antibodies directly on protein A beads suspended inside the settler to replace column chromatography, (iv) purify and separate ex vivo expanded mesenchymal stem cells from microcarrier beads, etc. C  SuviCa, Inc. Boulder www.suvica.com Discovery and development of small molecules for the treatment of cancer. C  Taiga Biotechnologies, Inc. Aurora www.taigabiotech.com Taiga Biotechnologies, Inc. is a clinical stage company focused on improving blood stem cell transplantation and harnessing the power of the immune system to fight infectious disease and cancer. Teleost Biopharmaceuticals Boulder www.teleostbio.com Teleost Biopharmaceuticals will help people protect themselves from sun damage by stimulating melanin production in the body by a method not triggered by the sun’s UV rays. The BioCollective, LLC Centennial www.thebiocollective.com Biobanking company for microbiome samples. Initial research focus is on epigenetic impact of microbiome metabolites through technology developed by its partner, Topogen, using a topoisomerase reporter system. Rezolute Louisville, California www.rezolutebio.com Rezolute is a clinical stage biopharmaceutical company specializing in the development of innovative drug therapies to improve the lives of patients with metabolic and orphan diseases. Rezolute is advancing a diversified portfolio including: RZ358 (Phase 2), an antibody for the ultra-orphan indication of Congenital HyperInsulinism (CHI), with an abbreviated path-to-market strategy; AB101 (Phase 1), a once-weekly injectable basal insulin with the potential to transform the treatment landscape in diabetes management by reducing the therapeutic burden for patients and improving compliance; and a Plasma Kallikrein Inhibitor (PKI) portfolio with two lead compounds, RZ402 targeting Diabetic Macular Edema (DME) and RZ602 targeting Hereditary Angioedema (HAE), an orphan indication. Rocky Mountain Biosystems, Inc. Wheat Ridge Research and development of transdermal pharmaceuticals and delivery systems, cosmetic devices, and tissue adhesives. Rocky Mountain Diagnostics, Inc. Colorado Springs www.rmdiagnostics.com Provides immunodiagnostic assays and reagents for biogenic amines, research reagents, a CLIA certified reference laboratory and contract manufacturing services. Rocky Mountain Instrumental Laboratories Fort Collins www.rockylab.com Provides contract chromatographic and mass spectrometric analysis of pharmaceuticals (both traditional drugs and biotechnology products, such as proteins and peptides and oligonucleotides), veterinary and human endocrinology, and forensic toxicology. Rocky Mountain Reagents, Inc. Golden www.rmreagents.com Manufactures stains, culture media and chemistry solutions for the medical industry, as well as titration reagents, indicators, acids, bases, and a variety of chemicals for industrial uses. Saigene Biotech, Inc. Denver www.saigene.com Developing testing processes to identify harmful algae blooms. Sandoz Broomfield www.us.sandoz.com Focuses on pharmaceuticals, consumer health, generics, eye care and animal health. Therapeutic categories include anti- infectives, anti-arthritics, cardiovasculars, gastrointestinal agents & psychotherapeutics. C  Silvergate Pharmaceuticals, Inc. Greenwood Village www.silvergatepharma.com Developer and manufacturer of pharmaceutical products focused on the pediatric market. 50 BIOSCIENCECOLORADO / / 2018-2019