b'COLORADO LIFE SCIENCES COMPANIES RAISE A RECORD $2.4 BILLION IN 20212021 Major IPOs, Venture Capital Funding, and Government Funding Accelerate Health Innovation COLORADO$ 2.4BLIFE SCIENCES Colorados life sciences ecosystem raised $2.4 billion in 2021, a new record for the fast-growing communityFINANCING HISTORYthat includes companies at all stages of commercialization and academic and research institutions. Five-Year Totals2021 COLORADO LIFE SCIENCES FUNDINGby Type 2020$ 1.2B, Federal funding totaling more than $430PUBLIC CAPITALmillion supported critical life sciences research2019 $ 2.6Band development at Colorado companies$ 1.35 Billion $ 850M,(Includes Invitae acquisitionPRIVATE CAPITAL $ 12.1B of ArcherDX) and academic and research institutions.2018Sources of federal grants for life sciences in Colorado$ 1B (Includes Pfizer acquisition included the Biomedical Advanced Research and$ 457.6 Million 2017Development Authority (BARDA), Department of$ 1.35B of Array Biopharma)Defense, Department of Energy, National InstitutesFEDERAL GRANTSof Health (NIH), and the National Science Foundation$ 430.2 Million Colorado BioScience Association tracks annual life sciences financings using publicly available sources, including company news releases, media reports, SEC filings, (NSF), many of which are deployed through the Small Business Innovation Research (SBIR) and Smallfederal and state databases, and Crunchbase.Business Technology Transfer (STTR) programs.MERGERS & ACQUISITIONSThe University of Colorado system and the Colorado State$ 167.5 MillionUniversity system were the states largest recipients of federal grants, all from the National Institutes of Health.STATE GRANTS - ADVANCEDINDUSTRIES ACCELERATOR GRANTS GRAND TOTAL$ 8.7 Million$ 2.4 Billion 5.8 MillionFOUNDATION GRANTS$VENTURE CAPITAL TOTALS$ 2.4 Million $ 150.0 Million Contributing to Society through HealthcarePRE-SEED AND SEED SERIES C, D, AND EThrough the technologies we provide and partnerships we forge, we unlock the potential of blood and cellular therapies to ultimately enable $ 240.4 Million $ 54.9 Million better lives for patients throughout the world.TERUMOBCT.COM SERIES A AND B VENTURE CAPITALSERIES UNKNOWN 2020 Terumo BCT, Inc.CO-NONP-0006236 BIOSCIENCECOLORADO 2022-2023 2022-2023 BIOSCIENCECOLORADO 37'